The Things They Carried
Despite Dean's directive to forget about looking for a cure for the Mark of Cain, Sam continues to do research. Dean suspects Sam is hiding something but decides to focus on a new murder case where they run into Cole. The three team up and learn a Khan worm is infecting men and turning them into murderers. Unfortunately, the worm makes its way into Cole.
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S10 E1
Black
Dean is a demon and running amuck with Crowley while Sam tries to figure out what happened to his brother. Meanwhile, Castiel is dealing with his fading grace.
S10 E2
Reichenbach
Crowley is worried that Dean, driven by the mark, is getting out of control. Sam struggles to escape from Cole. Hannah tries to convince Metatron to give Castiel his grace back.
S10 E3
Soul Survivor
Sam continues to try to save Dean from the Mark of Cain. Realizing that Dean's antics are causing problems for him in hell, Crowley seeks help from a reluctant Castiel.
S10 E4
Paper Moon
Sam and Dean investigate a series of werewolf attacks.